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An Autopsy Case of Autoimmune Pancreatitis

Context Autoimmune pancreatitis is an increasingly recognized type of chronic pancreatitis, but little is known about the long-term outcome of the disease. Case report We report an autopsy case of autoimmune pancreatitis. The patient was an 81-year-old Japanese male. He was referred to our department with jaundice in February 1996. ERCP images revealed a severe stricture of the lower part of the common bile duct and irregular narrowing of the main pancreatic duct. A diagnosis of extrahepatic cholangiocarcinoma was made and endoscopic biliary drainage was performed. A stricture of the common bile duct and narrowing of the pancreatic duct had improved on ERCP images when a follow-up examination was performed in November 1998. He was followed up for chronic pancreatitis. The serum IgG and IgG4 levels were increased on serological examination. He died of interstitial pneumonia and congestive heart failure in May 2003. At the autopsy examination, fibrosis was found in the periductal, interlobular and intralobular parts of the pancreas. Focal atrophy of the acinar cells was also identified. There was little infiltration of inflammatory cells into the parenchyma or the stroma of the pancreas. These pathological findings were similar to those of ‘conventional’ chronic pancreatitis. Conclusion We present an autopsy case of autoimmune pancreatitis which is a rare finding.


Yohei Kitano, Kakuya Matsumoto, Kenji Chisaka, Masako Imazawa, Kenji Takahashi, Yukiomi Nakade, Mituyoshi Okada, Kazunobu Aso, Masakazu Haneda, Kazunori Yokoyama, Masahiro Yamamoto, Masumi Yoshie, Katsuhiro Ogawa

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