Abstract

Management of Alcohol Use Disorders in Patients with Chronic Pancreatitis

Context The outcome of treatment for patients with chronic pancreatitis may be improved by multidisciplinary management.Objective To study patients with chronic pancreatitis, especially regarding alcohol use, within a multi disciplinary program. Main outcome measures Prospective assessment at baseline and follow-up of alcohol use disorders using DSM-IV criteria, AUDIT score, interview-based quantification of alcohol intake and the biomarker for alcohol use s-CDT in patients referred because of chronic pancreatitis together with retrospective classification with the M-ANNHEIM risk factor analysis and severity scoring for chronic pancreatitis. Results Sixty patients (95%) of 63 consecutively included patients were classified as having chronic pancreatitis. Forty four of these (73%) were available for follow-up evaluation, which took place after a minimum of 1 year (median 3 years). Alcohol consumption decreased at follow-up and no patients had ongoing alcohol dependence (P<0.001) as compared to 10 (23%) at initial evaluation. Patients with harmful alcohol use (AUDIT score ≥8 points) and pathological s-CDT had a reduction in both parameters (P=0.004 and P=0.063, respectively). Pain score according to M-ANNHEIM was unchanged, whereas use of analgesics decreased (P=0.005). Conclusions This feasibility study of patients with chronic pancreatitis demonstrated that multidisciplinary management seems to give a positive and sustainable effect on alcohol abuse and may be a useful concept for optimal classification, selection and treatment of patients with chronic pancreatitis.


Author(s):

Margareta B Lang , Ralf Segersvärd , Måns Grundsten , Märta Segerdahl , Urban Arnelo , Johan Permert , Johan Franck , Matthias Löhr , Jon A Tsai



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