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Pancreatic Pseudocysts Following Acute Pancreatitis: Risk Factors Influencing Therapeutic Outcomes

Context The natural history of pancreatic pseudocysts has become well known in recent years, but the choice of a proper treatment still remains controversial. Objective This study aims at establishing whether predictive factors influencing therapeutic outcomes exist. Setting Patients with pancreatic pseudocysts following an episode of acute pancreatitis treated from January 1980 to December 2001 at the Department of General Surgery and Organ Transplantation of the University of Parma, Italy. Patients :Seventy-four patients were studied: 12 had a spontaneous resolution, 37 patients were treated surgically, 15 were treated endoscopically and in 10, percutaneous drainage was used. Main outcome measures Epidemiological, clinical and pathological characteristics of patients with pancreatic pseudocysts were related to morbidity, recurrence rates and hospital stay. Results At univariate logistic regression, our data reveal a significant increase in morbidity related to age (P=0.013), etiology (alcoholic vs. biliary, P=0.024), Ranson score of previous pancreatitis (P=0.006), nutritional assessment (P=0.001), residual necrosis (P0.001) and modality of treatment (P=0.009), whereas none of these parameters has been shown to be  significantly correlated to recurrence. At multivariate logistic regresion, only residual necrosis was significantly related to morbidity. Conclusions Some factors, such as epidemiological (age, etiology), clinical (severity of previous pancreatitis, malnourishment), pathological (residual necrosis), and therapeutical  actors (emergency/urgency treatment) are predictive of worse outcomes for invasive treatment of pseudocysts. In particular residual necrosis appeared to be the most important factor influencing invasive treatment outcomes, confirming that this pathological aspect deserves particular attention from surgeons. No risk factors predicting pancreatic pseudocyst recurrence emerged.


Giulia Martina Cavestro, Francesco Di Mario, Mario Sianesi, Paolo Soliani, Christian Franzini, Stefanie Ziegler, Paolo Del Rio, Paolo Dell?Abate, Davide Piccolo, Gioacchino Giovanni Japichino

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