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Revisiting Metastatic Adult Pancreatoblastoma. A Case and Review of the Literature

Context Most cases of pancreatoblastoma, a rare tumor of neuroendocrine origin, are seen in the pediatric population. To date, at least sixteen case reports have been described of pancreatoblastoma in patients 19-year old or older. Surgical resection is the mainstay of curative treatment. Even patients with liver metastasis can have long-term disease-free survival. Case report One recent example is a 33-yearold male who presented to us for a right hepatic lobectomy for removal of the presumed primary tumor - later discovered to be a metastasis - followed by pancreaticoduodenectomy for resection of the true primary lesion. Five years after resection, this patient is the longest disease-free survivor of metastatic adult pancreatoblastoma. Conclusion We review the literature and propose that resection of pancreatoblastoma can offer long-term disease-free survival even with liver metastasis and microscopicallypositive surgical margins.


Kristofer M Charlton-Ouw, Christy L Kaiser, Guo-Xia Tong, John D Allendorf, John A Chabot

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