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Reply to: Platelet Aggregation, Platelet Serotonin and Pancreatitis

Konstantinos Mimidis*

8, Chrisostomou Smirnis str. GR-68 100 Alexandroupolis Greece

*Corresponding Author:
Konstantinos Mimidis
8, Chrisostomou Smirnis str.
GR-68 100 Alexandroupolis
Tel: +30-2551.074.090
Fax: +30-2551.030.324
E-mail: [email protected]

Received: June 1st, 2004

Visit for more related articles at JOP. Journal of the Pancreas




Platelet Adhesiveness; Platelet Aggregation


p-5HT: platelet-serotonin; SSRIs: selective serotonin-reuptake inhibitors


Dear Sir:

In response to the letter of Drs. Lechin and van der Dijs [1], we would like to express our gratitude concerning the additional information presented by the author. Indeed, the crucial role of platelet-serotonin (p-5HT) has been well-established in thrombogenesis and the release of serotonin has been proposed as the “gold standard” assay for the detection of thrombocyte activation [2].

However, the purpose of our study was to test a newly developed method of evaluating primary hemostasis based on the platelet function analyzer (PFA-100TM) in a prethrombotic model such as acute pancreatitis. This method had only been applied to hemorrhagic diathesis and its usefulness in thrombosis was unknown [3, 4, 5, 6]. Thus, we focused on testing the specific method rather than commenting on the underlying pathophysiology of platelets in acute pancreatitis.

In conclusion, the authors’ statements regarding the p-5HT levels and the potent use of selective serotonin-reuptake inhibitors (SSRIs) in acute pancreatitis serve as a valuable proposal for future studies.

Konstantinos Mimidis

Vassilios Papadopoulos


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