8, Chrisostomou Smirnis str. GR-68 100 Alexandroupolis Greece
Received: June 1st, 2004
Platelet Adhesiveness; Platelet Aggregation
p-5HT: platelet-serotonin; SSRIs: selective serotonin-reuptake inhibitors
In response to the letter of Drs. Lechin and van der Dijs , we would like to express our gratitude concerning the additional information presented by the author. Indeed, the crucial role of platelet-serotonin (p-5HT) has been well-established in thrombogenesis and the release of serotonin has been proposed as the “gold standard” assay for the detection of thrombocyte activation .
However, the purpose of our study was to test a newly developed method of evaluating primary hemostasis based on the platelet function analyzer (PFA-100TM) in a prethrombotic model such as acute pancreatitis. This method had only been applied to hemorrhagic diathesis and its usefulness in thrombosis was unknown [3, 4, 5, 6]. Thus, we focused on testing the specific method rather than commenting on the underlying pathophysiology of platelets in acute pancreatitis.
In conclusion, the authors’ statements regarding the p-5HT levels and the potent use of selective serotonin-reuptake inhibitors (SSRIs) in acute pancreatitis serve as a valuable proposal for future studies.
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