Abdulzahra Hussain1, Ali Adnan2, Shamsi El-Hasani1
1Department of General Surgery, Princess Royal University Hospital. Orpington, Greater London, United Kingdom. 2Otolaryngology, Head and Neck Department, Sahlgrenska University Hospital. Gothenburg, Sweden
Received August 8th, 2012 – Accepted October 2nd, 2012
Context Small cell carcinoma of the lung is an aggressive cancer with gloomy prognosis. Links to acute pancreatitis is extremely rare. Case report We are reporting a 53-year-old patient who was admitted because of acute pancreatitis. She had no history of gallstones, alcohol abuse, medications or any other predisposition for acute pancreatitis. Further investigations of blood, CT of chest abdomen and neck and ultrasound scan of abdomen, bone marrow and neck lymph node biopsies confirmed advanced small cell carcinoma of the lung with hypercalcemia, which was the only definite cause of acute pancreatitis. The patient made good recovery from pancreatitis after controlling the hypercalcemia. She was referred to respiratory team for further management of lung cancer. Conclusion Acute pancreatitis due to hypercalcemia of advanced small cell carcinoma of the lung is an extremely rare condition. Acute pancreatitis due to hypercalcemia should be thoroughly investigated to exclude serious pathology as in our case.
Carcinoma, Small Cell; Hypercalcemia; Pancreatitis, Acute Necrotizing
Lung cancer is the second commonest cancer in the UK. It is commonly presents with respiratory symptoms; however, some cases are diagnosed incidentally during investigation of unrelated symptoms. Some of the lung cancer cases presents with loco-regional and/or distant metastasis. Connection of lung cancer to pancreatitis is extremely rare . We are presenting a case of pancreatitis due to hypercalcemia of small cell carcinoma.
A 53-year-old lady presented with epigastric pain radiated to the back, nausea and vomiting of 3 days. She had no previous similar episode of pain. She had no history of gallstone disease or alcohol abuse. No history of recent infection, trauma, endoscopic procedure and no on regular medication. She had no significant past medical or surgical problems. Clinical examination on admission revealed normal vital signs, cervical lymphadenopathy and epigastric tenderness.
Her amylase was very high at 1,618 U/L (reference range: 0-100 U/L) but liver function test was abnormal: total bilirubin 11 μmol/L (1-17 μmol/L), total protein 62 g/L (64-83 g/L), albumin 40 g/L (35-50 g/L), globulin 22 g/L (18-36 g/L), alkaline phosphatase 217 U/L (35-104 U/L), alanine transaminase 137 U/L (0-40 U/L), aspartate transaminase 121 U/L (5-38 U/L), gamma-glutamyl transpeptidase 723 U/L (5-40 U/L), LDH 1,176 U/L (240-480 U/L), and C-reactive protein 7 mg/L (0-5 mg/L). The lipid profile was normal. Her thyroid function showed low thyroid stimulating hormone (TSH), low T3 and T4.
Pituitary magnetic resonance imaging scan showed no pituitary lesion. Chest and plain abdominal X-rays showed no free gas under diaphragm and no bowel obstruction. She had high calcium level at 2.89 mmol/L (2.15-2.60 mmol/L). Glasgow score was 1 and diagnosis of mild acute pancreatitis was made.
The patient was managed by supportive measures and made a progressive slow recovery after correction of hypercalcemia. The hypercalcemia was managed by fluids, frusemide and pamidronic acid and it was reversed to normal range.
Ultrasound and subsequent computerized tomography (CT) showed no gallstones but CT showed liver lesions which were reported initially as hemangiomas. On the 9th day of admission she developed swollen left upper limb. At that stage the radiology imaging were reviewed at the radiology multidisciplinary team meeting and her chest X-ray was compared to the previous one of two months which showed significant
mediastinal widening and chest CT was suggested and showed extensive mediastinal disease and left internal jugular vein thrombosis and compression of left subclavian vein (Figures 1-4). The radiologist suggested lymphoma as the primary malignancy; however, the bone marrow biopsy showed a cellular marrow extensively infiltrated by a high-grade malignant tumour composed of small cells with scanty cytoplasm. Numerous mitoses were seen. Immunocytochemistry demonstrated a strong positive reaction for CD56 and bcl2, while a focal positive reaction was seen for bcl6. Perinuclear dot positivity was seen for MNF116. A negative reaction was seen for CD79, CD20, CD34, CD23, CD10, CD5, CD3 and cyclin D1.
Heamatology and respiratory team were involved and bone marrow and lymph node biopsies were suggestive of small cell carcinoma of lung origin. The respiratory team took over the patient care.
Small cell carcinoma is affecting different organs including respiratory system . Links of small cell carcinoma to pancreatitis is usually through distant metastasis rather than other mechanisms  (Table 1). Our search of English literature showed 5 cases of hypercalcemia associated small cell cancers of different origins causing acute pancreatitis [4, 5, 6, 7].
Only two cases of small cell carcinoma of the lung causing acute pancreatitis were found [8, 9]. Hypercalcemia induces pancreatic injury via a secretory block, accumulation of secretory proteins, and possibly activation of proteases . It is a rare cause of pancreatitis. Hypercalcemia due to small lung carcinoma causing pancreatitis is an extremely unusual and probably this is the third case. The level of calcium could reach 3.87 mmol/L at the time of diagnosis .
Initial radiology report put less weight on the liver lesions; however, reviewing imaging and the commitment to find the cause of hypercalcemia in this case has helped to reach the definite diagnosis. Multidisciplinary teamwork was successful to diagnose and to instill management plan quickly.
Hypercalcemia due to small cell carcinoma of the lung causing acute pancreatitis is an extremely rare condition. Multidisciplinary team approach is important for successful diagnosis and early management.
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