A Case of Acute Pancreatitis Due to Liraglutide

Context Liraglutide is a long-acting glucagon-like peptide-1 (GLP-1) analog which has an important role in the management of glucose metabolism. Liraglutide also decreases caloric intake due to a reduction of appetite effect. As a result of such effects, liraglutide was developed for the treatment of type 2 diabetes and weight management. Observational studies and clinical trials data suggest an association between GLP-1 agonist use and acute pancreatitis and it has been suggested that acute pancreatitis is a potential complication of liraglutide therapy. Case report We present a case of acute pancreatitis occurred in a patient treated with liraglutide for weight management. All others potential causes of acute pancreatitis were ruled out. Conclusions Although more studies are needed to demonstrate the direct cause effect relation between liraglutide and acute pancreatitis, the trend of results found in the literature has positioned liraglutide as a potential risk factor of acute pancreatitis.


Noe Quesada-Vazquez, Jose Such, Pascale Anglade

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