Inflammation plays extremely critical and vital role in progression of type 2 diabetes mellitus. Relationship of C-reactive protein and interleukin-6 (IL-6) in obese T2DM and healthy subjects has been premeditated epidemiologically. However, experimental data addressing such concern has scarcely been published from Indian sub-continent. The current study was designed to generate baseline data and to verify existing association between C-reactive protein and IL6 with obesity and uncontrolled progression of T2DM of among Pakistani patients. One hundred fifty T2DM patients (Group I) and fifty healthy subjects with normal levels of CRP and IL-6 (Group II) were included in the study Physical and biochemical parameters were calculated to evaluate the link of bio-inflammatory markers (CRP and IL-6) with uncontrolled T2DM. Physical parameters were observed to be high among obese T2DM subjects than healthy subjects. Serum CRP and IL-6 levels appeared positively correlated to physical parameters. The relationship of CRP and IL-6 with glycaemic control was calculated with HbA1c. It is revealed that both C-reactive protein and IL-6 are sensitive markers in uncontrolled T2DM in obese diabetic patients predicting its severity and may be the rapid progression of diabetic complications. To the best of our knowledge and search through available literature, thisappears isthe first report on relationship between inflammatory sensitive markers (CRP and IL-6) and progression of various T2DM complications among obese T2DM patients in Pakistani population. Need of study Present study needs to finds association, within the indigenous papulation, of elevated biochemical levels of both C-reactive protein and IL-6 with polymorphisms of C-reactive protein and IL-6 genes.
Naila Abdul Sattar, Sumera Shaheen, Siraj-udin Sajid