Background Abdominal ultrasound and computed tomography (CT) utilization in pancreatic imaging has been found invaluable in the evaluation of pancreatic lesions. Although the gold standard modality for imaging of pancreas, CT is fraught with the limitations of radiation risk, cost and availability. Ultrasound (US) imaging of the pancreas is cost effective, readily available with no radiation risk but it is operator-dependent and limited by bowel gas. Comparative study of CT and US biometry of pancreas in normal adult population in Lagos State Nigeria has not been established. Method A prospective cross-sectional study of 150 apparently normal adult patients who underwent both CT scan and ultrasonography (US) at Clinix Healthcare Ilupeju, Lagos State, and who met the inclusion criteria, was carried out. Anterior-posterior (AP) dimensions of the pancreatic head, body and tail were obtained at right angles to the longitudinal axis of the organ. Results On US, the mean AP dimensions of the pancreas head, body, and tail in the studied population were 25.10 ± 2.75 mm, 15.98 ± 1.86 mm, and 13.50 ± 1.53mm respectively. On CT, the mean ± SD AP pancreas dimensions of head, body, and tail in the studied population were 26.77 ± 2.68 mm, 21.19 ± 2.12 mm, and 17.25 ± 2.12mm respectively. Conclusion AP dimensions of the pancreas segments measured on CT were significantly larger than that measured on US (P= 0.000), and CT is better modality in demonstration of pancreas segments especially the tail.