Giant Acinar Cell Carcinoma of Pancreas Presenting In a Young Patient

Context Acinar cell carcinoma is rare disease of exocrine pancreas with an indolent course and favorable tumor biology. It usually occurs in elderly male patient. However, its occurrence in young patient with large size is rarer. Case report A 28 year male patient presented with abdominal pain and mobile epigastric lump for 6 months and jaundice for 2 week duration. Contrast enhanced computed tomography revealed giant (15×13 cm) heterogeneously enhancing tumor arising exophytically from pancreatic head and compressing splenoportal axis and common hepatic artery, which was successfully managed with artery first pancreaticoduodenectomy. Histopathological examination with immunohistochemistry revealed acinar cell carcinoma of pancreas. Conclusion Differential diagnosis of acinar cell carcinoma of pancreas should be considered in young patient with large tumor size. Prognosis is better than adenocarcinoma of pancreas because of its favorable tumor biology. Surgical resection with curative intent along with multimodality regimen is preferred treatment modality.


Narendra Pandit, Rupesh Sah, Lalijan Awale, Lokesh Shekher Jaiswal, Shailesh Adhikary

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