Pancreatic Glucagonoma Metastasising to the Right Ovary Five Years after Initial Surgery: A Case Report

Context Glucagonomas of the pancreas are neuroendocrine tumours (NETs) that arise from well-differentiatedneuroendocrine cells within the pancreatic islets. They are considered to be aggressive NETs and often have metastases atinitial presentation. In contrast localised glucagonoma without metastatic spread may have prolonged disease free survivalwith radical resectional surgery. Case report The authors present a case of a glucagonoma that initially presented withclassical necrolytic migratory erythema and a large solitary mass in the body and tail of the pancreas that was surgicallyresected. Five years after surgery the patient presented with increased serum glucagon levels and a mass in the right ovary.Pathology of the resected ovary after oophorectomy identified this as an isolated metastatic glucagonoma. Conclusion Glucagonoma is a rare pancreatic NET that has significant malignant potential. This is the first case of a pancreaticglucagonoma metastasising to the ovary 5 years after radical distal pancreatosplenectomy.


David Graham Watt, Sanjay Pandanaboyana, Charles Simon Herrington, Iain S Tait

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