Context Lymphoepithelioma-like carcinomas are rare, non-keratinizing and undifferentiated carcinomas, with a distinctive syncytial growth pattern, and with associated numerous non-neoplastic lymphocytes admixed with the tumor cells. The majority of tumors with this appearance are Epstein Barr virusassociated. Case report We report a case of a forty-one-year-old male patient who had a pancreatoduodenectomy for a periampullary lymphoepithelioma-like carcinoma. Epstein-Barr Virus-Encoded RNA in situ hybridization was positive. Immunohistochemistry for mismatch repair proteins showed that the tumor cells were positive (normal staining pattern) for MSH-2, MSH-6, MLH-1 and PMS-2. Conclusion Peri-ampullary lymphoepithelioma-like carcinomas have not been previously described in the published English literature. We review the morphological, immunohistochemical and molecular features of lymphoepithelioma-like carcinomas.
Aoife J McCarthy, Runjan Chetty
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