Peri-Ampullary Lymphoepithelioma-Like Carcinoma: Case Report and Review of the Literature

Context Lymphoepithelioma-like carcinomas are rare, non-keratinizing and undifferentiated carcinomas, with a distinctive syncytial growth pattern, and with associated numerous non-neoplastic lymphocytes admixed with the tumor cells. The majority of tumors with this appearance are Epstein Barr virusassociated. Case report We report a case of a forty-one-year-old male patient who had a pancreatoduodenectomy for a periampullary lymphoepithelioma-like carcinoma. Epstein-Barr Virus-Encoded RNA in situ hybridization was positive. Immunohistochemistry for mismatch repair proteins showed that the tumor cells were positive (normal staining pattern) for MSH-2, MSH-6, MLH-1 and PMS-2. Conclusion Peri-ampullary lymphoepithelioma-like carcinomas have not been previously described in the published English literature. We review the morphological, immunohistochemical and molecular features of lymphoepithelioma-like carcinomas.


Aoife J McCarthy, Runjan Chetty

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+

Abstracted/Indexed in

  • Index Copernicus
  • Academic Journals Database
  • Genamics JournalSeek
  • Academic Keys
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • British Library
  • Electronic Journals Library
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Emerging Sources Citation Index (ESCI)
  • EBSCO Host
  • MIAR
  • International Committee of Medical Journal Editors (ICMJE)
  • University of Zurich - UZH
  • University Grants Commission
  • SWB Online-Katalog
  • Scholarsteer
  • Geneva Foundation for Medical Education and Research
Flyer image