Context Purulent complications worsens prognosis in patients with acute necrotizing pancreatitis. Early diagnosis of infection development can improve results of their management. Objective Aim of our research was to establish utility of presepsin for diagnosis of local and system infected complications during acute necrotizing pancreatitis. Methods Prospective study of 70 patients with severe acute necrotizing pancreatitis in a single intensive care department of regional hospital has been performed. Levels of presepsin before any invasive treatment were determined and compared with results of bacteriological investigation of pancreatic tissue. Findings The positive results of bacteriological examination were obtained in 43 patients. The rate of presepsin was three-four times higher in the patients with infected complications than those in the individuals with sterile pancreatic necrosis. Increasing the presepsin rate above 632 pg / ml allows confirming the presence of both local and systemic infection with high sensitivity and specificity. Receiver-operating characteristic AUC of presepsin diagnostic utility for all types of infected complications of acute necrotizing pancreatitis reached 0.956, ÃÂÃÂ¡ÃÂÃâ 0.883-0.972, pÃâ¹Ãâ0.01. Conclusion Presepsin concentration is early highly sensitive and specific marker for all kind of infected complications of acute necrotizing pancreatitis.
Oleksandr Rotar, Igor Khomiak, Michail Nazarchuck, Vasyl Rotar, Andrii Khomiak, Krishna Taneja, Sitlana Railianu