Mucinous Cystic Neoplasm of the Pancreas in a Male Patient Diagnosed by Endoscopic Ultrasonography

Keiko Kamei, Ippei Matsumoto*, Yoshifumi Takeyama

Department of Surgery, Kinki University Faculty of Medicine, Osaka, Japan

*Corresponding Author:
Ippei Matsumoto
Department of Surgery, Kinki University Faculty of Medicine
377-2 Ohno-higashi, Osaka-Sayama 589-8511, Japan
Phone +81-72-366-0221
Fax +81-72-367-7771
E-mail [email protected]

Received September 09th, 2015 Accepted October 25th, 2015

 
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Abstract

  

TEXT

Based on World Health Organization (WHO) criteria, Mucinous cystic neoplasms (MCNs) of the pancreas are defined as cystic epitheilal neoplasms composed of mucin producing colomnar epithelium and an ovariantype stroma (OS) [1]. Diagnosis and surgical resection of MCN are imporatnt because of its significant malignant potential. MCNs almost always occur in women. We present a case of MCN in a male patient diagnosed by endoscopic ultrasonography (EUS) preoperatively.

A 59-year-old man with an asymptomatic cystic lesion in the pancreatic body was referred to our hospital. The abdominal CT scan revealed a 30-mm unilocular cystic lesion in the pancreatic body (Figure 1). Magnetic resonance imaging (MRI) showed a hypointense mass lesion in T1-weighted imaging, and hyperintense in T2-weighted imaging. Magnetic resonance chplangiopancreatography (MRCP) showed a unilocular cystic lesion in the pancreatic body without dilatation of the main pancreatic duct (Figure 2). EUS revealed “cyst in cyst” appearance and a mural nodul in the lesion (Figure 3). He underwent laparoscopic distal pancreatectomy with a preoperative diagnosis of a MCN. Histologically, the cystic lesion revealed low grade dysplasia with an OS (Figure 4). Immunohistochemically, the stromal layer was positive for progesteron and estrogen receptors. MCN was finally diagnosed.

pancreas-unilocular-cystic

Figure 1. The abdominal CT scan revealed a 30-mm unilocular cystic lesion in the pancreatic body.

pancreas-resonance-cholangiopancreatographyc

Figure 2. Magnetic resonance cholangiopancreatography showed a unilocular cystic lesion in the pancreatic body without dilatation of the main pancreatic duct.

pancreas-endoscopic-ultrasonography

Figure 3. Endosc opic ultrasonography showed “cyst in cyst” appearance and a mural nodule in the cystic lesion.

pancreas-low-grade-dysplasia

Figure 4. The cystic lesion revealed low grade dysplasia with an ovarianlike stroma.

Diagnostic errors of cystic lesions of the pancreas are quite common. The overall accuracy of the preoperative diagnosis was 60.9% [2]. MCNs typically appear as large unilocular or multilocular cysts with thin septase on CT or MRI. Differential diagnosis is still dificul especially in case of unilocular lesion because other pancreatic neoplastic lesions sometimes appear unilocular cyst. EUS may be more helpful for the diagnosis and differentiation of the cystic lesion because of its high resolution and better imaging characteristics than other modatities [3]. EUS was also useful for diagnosis in our case. Although the frequency of “cyst in cyst” appearance of MCN on EUS has been reported not so high as 38 %, it is a specific feature of MCN on EUS [4].

To our knowledge, only 13 cases of MCNs were reported in men since intraductal papillary mucinous neplasm and MCN clearly defined by the WHO (Table 1). Of these, only 8 cases were described in detail. Recently, a multiinstitutional study of the Japan Pancreas Society reported only 3 men (1.9%) of 156 MCN patients with OS [5]. Among the 8 cases described in detail, CT were conducted in all cases, MRI in 6, and EUS in 4. However, in all but our case, the preoperative diagnosis was different from MCN because MCN almost exclusively occur in female, and the imaging studies do not infrequently show typical findings of MCN.

We present an extremely rare case of MCN in a male patient diagnosed by EUS with typical findings. MCN should be considered in the differential diagnosis of pancreatic lesion in men, as well as women.

Acknowledgments

We would like to thank Dr. Kitano M and Chikugo T for conducting EUS and histological diagnosis.

Conflict of Interests

Authors declare no conflict of interests for this article.

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